Clotting mechanism – Enzyme cascade theory

Clotting – It is defined as the process in which blood looses it’s fluidity and becomes a jelly like substance few minutes after it is shed out.

Sequence of clotting mechanism – Enzyme cascade theory:

Cascade is a process that occurs through a series of steps , each step initiating the next until the final step is reached.

Stages of blood clotting :

  • Formation of prothrombin activator
  • Conversion of prothrombin into thrombin
  • Conversion of fibrinogen into fibrin

Sources – Sembulingam (Textbook of physiology)

Image source – Google images

Odontogenic Infections

Written by - Dr.Urusa I Inamdar

An odontogenic infection is an infection of the alveolus,jaws, or face that originates from a tooth or from its supporting structures and is one of the most frequently encountered infections.

Causes

  • dental caries
  • deep fillings
  • failed root canal treatment
  • periodontal disease
  • pericoronitis

Localised and spreading of odontogenic infection

infections have the potential to spread to other areas of the maxillofacial region and beyond through tissue planes and bloodstream.

A spreading odontogenic infection presents with varying degrees of facial swelling , trismus and pain , and can be life threatening.

Signs and symptoms

  • pain in the oral cavity and jaws
  • Swelling
  • mobile tooth
  • tenderness on biting or tapping on the affected tooth
  • Pain on Palpation of the surrounding gum
  • spontaneous drainage of pus

Red Flag suggestive of

  • Difficulty in speaking , swallowing and breathing
  • Dehydration
  • Trismus
  • Pyrexia
  • Raised tongue and floor of the mouth , drooling
  • Tachycardia and tachypnoae
  • Hypotension
  • Increased white blood cell count
  • Lymphadenopathy
  • Periorbital cellulitis

Clinical presentation

  • Dentoalveolar infection– swelling of the alveolar ridge with periodontal, periapical and subperiosteal abscess.
  • Submental space infection– firm midline swelling beneath the chin, caused by infection from the mandibular incisor.
  • Submandibular space infection– swelling of the Submandibular triangle of the neck around the angle of the mandible, caused by mandibular molars infection.
  • Sublingual space infection– swelling of the floor of the mouth with possible elevation of the tongue and dysphagia.
  • Retro pharyngeal space infection– stiff neck, sore throat, dysphagia and raspy voice, caused by the infections of the molars. It has high potential to spread to the mediastinum.
  • Buccal space infection– swelling of the cheek caused by infection of premolars and molars.
  • Masticator space infection– swelling on either side of the mandibular ramus, caused by infection of the mandibular third molars. Trismus is present.
  • Canine space infection– swelling of the anterior cheek with loss of the nasolabial fold and possible extension to the infraorbital region.

Complications of odontogenic Infections

  • respirtory obstruction
  • Sepsis
  • Endocarditis
  • Pericarditis
  • Necrotising fascitis
  • descending mediastinitis
  • spondylitis
  • brain abscess
  • cavernous sinus thrombosis
  • thoracic empyema
  • pleuropulmonary suppuration
  • aspiration pneumonia
  • pneumothorax
  • mandibular or Cervical osteomyelitis
  • abscess of the carotid sheath and jugular thrombophlebitis
  • hematogenous dissemination to distant organs and coagulation abnormalities.

References

  • Ogle OE . Odontogenic Infections. Dent Clin North Am.
  • gskpro.com ( Understanding Odontogenic Infections and its complications )
  • Shafer’s Textbook of Oral Pathology ( 7th edition )

SYNCOPE

Vasovagal Syncope

Common faint
🔹Predisposing factors:
  • Hot/crowded enviornment
  • Fatique
  • Pain
  • Prolonged standing
  • Hunger, emotional
🔹Pathophysiology:

Prolonged standing

⬇️

⬇️ filling of Ventricle

⬇️

Venous pooling

⬇️

⬆️ sympathetic activation

⬇️

contraction of Ventricle

⬇️

Stimulation of Myocardial mechanoreceptors & vagal afferent fibers

⬇️

Vasodilation & Bradycardia

⬇️

Hypotension & Syncope

🔹Management:
Presyncope
•Stop the procedure
•Patient placed supine with legs slightly elevated
•Muscular movements, aids the return of blood from periphery
•If thought necessary, oxygen may be administered, using full-face mask or nasal hood.
•An ammonia ampule may be crushed and held under patient’s nose.
•Postponement of dental procedure.
Dr. Mehnaz Memon🖊

References: Practical medicine guide by PJ Mehta; Internet