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Rabie et al., Angle Orthodontist, 2003;73:457–465

Stepwise mandibular advancement → Mechanical strain → ↑ Replicating mesenchymal cells → ↑ Osteoprogenitor population → ↑ Bone formation → ↑ Condylar growth potential
| Parameter | Details |
|---|---|
| Animal | 250 female Sprague-Dawley rats |
| Age | 35 days |
| Control | Natural growth |
| One-step (OS) | 3.5 mm advancement + 3 mm inferior displacement |
| Stepwise (SW) | 2 mm initial advancement → +1.5 mm on Day 30 |
| Cell marker | BrdU immunostaining |
| Assessment | Replicating mesenchymal cells + new bone formation |
| Regions studied | Anterior, middle & posterior condyle |
| Main site of response | Posterior condyle |
Forward mandibular positioning
↓
Stretching of posterior condylar tissues
↓
Mechanical strain
↓
↑ Mesenchymal cell replication
↓
Mesenchymal cells → chondroblasts / osteoblasts
↓
Cartilage formation + vascular invasion
↓
Endochondral ossification
↓
First advancement: 2 mm
Second advancement: +1.5 mm on Day 30
Cell proliferation precedes bone formation.
| Feature | One-Step | Stepwise |
|---|---|---|
| Advancement | 3.5 mm at once | 2 mm → +1.5 mm |
| Initial cellular response | Greater | Lower |
| Cell replication | Early increase → declines | Repeated increase after each advancement |
| Bone formation | Early peak → declines | Sustained/repeated increase |
| Long-term effect | Returns toward natural growth | Greater bone formation |
| Day 60 bone formation | Similar to natural growth | 49% higher |
First advancement
→ recruits mesenchymal cells
→ cells proliferate
→ differentiate
→ bone formation
Second advancement
→ provides new mechanical stimulus
→ recruits another population of replicating cells
→ increases osteoprogenitor pool
→ additional bone formation
“Advance → Recruit → Differentiate → Form bone → Advance again → Recruit again.”
Rabie et al. demonstrated that stepwise mandibular advancement produces repeated mechanical strain, increasing mesenchymal cell replication in the posterior condyle; this expands the osteoprogenitor cell population and subsequently enhances endochondral bone formation and condylar growth potential.
Banks P, Carmichael G.
JCO. 1999;33(11):620–623.
Instead of advancing the mandible immediately to an edge-to-edge incisor position, advancement is performed gradually using chairside-activated advancement screws + acetal resin spacers.
Large overjet + limited mandibular protrusion → gradual advancement without forcing the mandible forward.
Edge-to-edge bite registration
⬇️
May cause:
Small initial advancement
⬇️
Adaptation
⬇️
Progressive advancement
⬇️
Reduced overjet
✅ Greater orthopedic effect
✅ Less incisor tilting
✅ Better patient comfort
✅ Better speech
✅ Improved compliance
✅ Better appliance positioning during sleep
Maxillary appliance blocks
⬇️
Contain advancement screws
⬇️
Activated by inserting:
Different spacer thicknesses allow controlled incremental advancement.
| Screw | Maximum/indicated advancement |
|---|---|
| Standard screw | Up to 7 mm |
| 16 mm screw | For greater activation |
| 20 mm screw | For very large advancement |
Up to 12 mm stepwise advancement
12-year-old female
Modified Twin-Block
→ Stepwise mandibular advancement
→ Correct overjet
Extraction of maxillary first premolars
Fixed appliances
→ Align and level both arches
Overjet = 12 mm
Maximum comfortable protrusion = only 3 mm
⬇️
3 mm
⬇️ 6–8 weeks
+3 mm spacer
⬇️ 6–8 weeks
+3 mm spacer
⬇️ 6–8 weeks
+2 mm spacer
⬇️
3 + 3 + 3 + 2 = 11 mm
⬇️
Overjet reduced to 0 mm
| Stage | Duration |
|---|---|
| Active Twin-Block phase | 7 months |
| Continued full-time wear | 2 additional months |
| Maxillary first premolar extraction | During continued Twin-Block wear |
| Fixed appliance therapy | 17 months |
| Total active treatment | 24 months |
12 mm overjet
but
Only 3 mm initially
⬇️
❌ Immediate large advancement difficult
⬇️
✅ Start with 3 mm advancement
⬇️
Gradually add spacers
⬇️
Progressive mandibular advancement
⬇️
1. Assess maximum comfortable mandibular protrusion
↓
2. Start with a small advancement
↓
3. Allow neuromuscular adaptation
↓
4. Review at approximately 6–8 weeks
↓
5. Add bilateral spacers
↓
6. Reassess overjet and patient comfort
↓
7. Continue progressive advancement until correction
⭐ Severe overjet
⭐ Limited mandibular protrusive movement
⭐ Patients unable to posture edge-to-edge
⭐ Patients who may not tolerate large initial advancement
⭐ Cases requiring large total mandibular advancement
Initial mandibular advancement
with
Total required overjet correction
Initial advancement: 3 mm
Overjet: 12 mm
The patient does not need to achieve 12 mm advancement immediately.
Instead:
Small advancement → adaptation → reactivation → further advancement
🔹 Modified Twin-Block allows chairside progressive mandibular advancement
🔹 Advancement achieved using screws + cylindrical acetal resin spacers
🔹 Initial advancement can be small when mandibular protrusion is restricted
🔹 3 + 3 + 3 + 2 mm incremental advancement in the reported case
🔹 12 mm overjet → 0 mm overjet
🔹 Active Twin-Block phase: 7 months
🔹 Total active treatment: 24 months
🔹 16 mm and 20 mm screws may be required for greater activation
Banks and Carmichael described a modified Twin-Block appliance that permits controlled, progressive mandibular advancement using advancement screws incorporated into the maxillary blocks and cylindrical acetal resin spacers. This approach is particularly advantageous in patients with severe overjet who cannot initially posture the mandible to an edge-to-edge position. By using small incremental advancements at 6–8-week intervals, muscular adaptation and patient comfort may be improved while potentially reducing unwanted incisor tipping. In the reported 12-year-old patient, an initial 3 mm advancement was progressively increased by 3 mm, 3 mm and 2 mm spacers, reducing a 12 mm overjet to zero over a 7-month Twin-Block phase.
“Can’t advance 12 mm? Don’t force it—start at 3 mm, adapt, add spacers, and advance step-by-step.”
Ng J, Major PW, Heo G, Flores-Mir C.
American Journal of Orthodontics and Dentofacial Orthopedics. 2005;128:212–219.
To determine how much true incisor intrusion is actually achieved during orthodontic treatment.
When incisors appear to intrude clinically, how much is genuine intrusion versus apparent intrusion caused by growth or other tooth movements?
Apical movement of the tooth’s center of resistance/root relative to a stable skeletal reference.
Clinical crown appears to move apically
≠
True intrusion of the entire tooth
Apparent intrusion may result from:
| Incisor group | Mean true intrusion |
|---|---|
| Maxillary incisors | ~1.5 mm |
| Mandibular incisors | ~1.9 mm |
True incisor intrusion is possible, but the amount achieved is relatively small.
Forces should be directed through or near the center of resistance.
Correct force vector
→ Intrusive movement
Incorrect force vector
→ Intrusion + tipping
Loss of posterior anchorage may produce:
Posterior extrusion
↓
Mandibular clockwise rotation
↓
Apparent bite opening
This may be mistaken for true incisor intrusion.
In growing patients:
may influence measured intrusion.
Labial tipping of incisors
can produce an apparent reduction in overbite without equivalent bodily intrusion.
Ng et al. (2005), in a systematic review and meta-analysis, evaluated the amount of true incisor intrusion achieved during orthodontic treatment. The study demonstrated that genuine incisor intrusion is achievable, but the magnitude is relatively limited, approximately 1.5 mm for maxillary incisors and 1.9 mm for mandibular incisors. Therefore, the reduction in overbite observed clinically should not be attributed entirely to true incisor intrusion, as it may also result from incisor inclination changes, posterior tooth extrusion, mandibular rotation, and growth-related changes. This finding emphasizes the importance of distinguishing true intrusion from apparent or pseudo-intrusion when evaluating deep-bite correction.
“Deep bite correction ≠ pure intrusion; true intrusion is modest—~1.5 mm upper, ~1.9 mm lower.”
Danz JC et al. European Journal of Orthodontics. 2014;36:522–530
| Parameter | Finding |
|---|---|
| Study design | Retrospective long-term follow-up |
| Original sample | 855 former orthodontic patients |
| Eligible deep bite cases | 185 |
| Final analyzed complete-treatment sample | 43 |
| Relapse cases | 4/43 |
| Median follow-up | 11.9 years |
| Relapse definition | Incisor overlap <50% after treatment → ≥50% at follow-up |
| Relapse prevalence | 10.3% |
| Median increase in overlap in relapse group | 6.7% |
| Range of increase | 3.2–19.8% |
| Stable cases | ~90% |
| Major conclusion | Long-term vertical relapse was low and clinically small |
Increased vertical overlap of maxillary and mandibular incisors
Measured as:
1. Dentoalveolar
2. Skeletal
Growth
→ Mandibular growth rotation
Function
→ Muscular and functional influences
Dental changes
→ Incisor overeruption
→ Loss of arch form
→ Lower incisor crowding
→ Upper anterior spacing
Periodontal remodeling
→ Reorganization of periodontal tissues
Retention
→ Inadequate or absent retention
Treatment outcome
→ Incomplete leveling
→ Persistent deep bite
→ Poor incisor contact
Other factors
→ Lower lip pressure
→ Sagittal relapse
→ Bolton discrepancy
→ Interincisal angle
↓
Intrude upper and/or lower incisors
Best when: Excessive incisor eruption contributes to deep bite
↓
Pseudo-intrusion
Incisor proclination increases effective vertical clearance.
↓
Posterior tooth eruption
↓
Possible clockwise mandibular rotation
↓
↑ Lower anterior facial height
↓
Open bite / reduce deep bite
⚠️ Clockwise rotation does not necessarily occur in every patient.
More stable than expected
90% remained without vertical relapse
Only 10.3% demonstrated recurrence to ≥50% incisor overlap.
And even in these cases:
The amount of relapse was small
Median increase = 6.7%
This is the most clinically important message from the study.
T1: Deep bite
↓
T2: Successfully corrected
↓
T3: Deep bite returns
T1: Deep bite
↓
T2: Still deep bite
↓
T3: Deep bite persists or worsens
Deep bite at long-term follow-up was more likely due to PARTIAL CORRECTION than TRUE RELAPSE.
| Group | Deep bite at T3 |
|---|---|
| True relapse | 4 patients |
| Partial treatment | 7 patients |
Finish the correction!
Incomplete leveling and incomplete establishment of anterior contact may be more problematic than relapse after successful correction.
Persistent deep bite + incomplete treatment
→ ↑ Gingival contact
→ ↑ Palatal impingement
→ ↑ Risk of traumatic contact
In the relapse group:
Absence of retention may facilitate:
⚠️ However: The study was not large enough to prove retention as a relapse risk factor.
Possible explanations:
Median age at T2 ≈ 17 years
↓ Less remaining growth
More periodontal remodeling may have occurred before debonding.
Majority received:
Most patients achieved:
The study could not identify reliable predictors of deep bite relapse because:
No clinically reliable prediction model for individual deep bite relapse could be established.
☐ Deep bite fully corrected
☐ Curve of Spee adequately leveled
☐ Stable anterior incisor contact
☐ No gingival contact
☐ No palatal impingement
☐ Evaluate incisor inclination
☐ Assess interincisal angle
☐ Check arch form
☐ Check anterior spacing
☐ Evaluate sagittal relationship
☐ Plan long-term retention
Monitor for:
🔍 Increased overbite
🔍 Loss of anterior contact
🔍 Upper anterior spacing
🔍 Lower anterior crowding
🔍 Loss of arch length
🔍 Sagittal relapse
🔍 Growth-related mandibular rotation
Long-term relapse of successfully treated moderate deep bite was relatively uncommon and small. Approximately 90% remained stable after a median 11.9-year follow-up, while 10.3% showed relapse, with a median increase in incisor overlap of only 6.7%. Importantly, persistent deep bite at long-term follow-up was more commonly associated with incomplete treatment than true relapse.
“Correct it completely → Establish anterior contact → Retain it → Relapse is usually small.”