It is a sulphone, oldest and cheapest ; most widely used for leprosy

MECHANISM OF ACTION

ADVERSE EFFECTS

Dose related hemolytic anemia in G6PD deficiency,

OTHERS: Anorexia, Nausea, Vomiting, Fever, Headache, Allergic dermatitis, Itching, Peripheral neuropathy, Methaemoglobin

Exacerbation of lesions- ‘ sulphone syndrome‘:- fever, dermatitis, pruritis, lymphadenopathy, methaemoglobinaemia, anemia, hepatitis

PHARMACOKINETICS

🟡 Given orally

🟡 almost completely absorbed from gut

🟡 bound to plasma proteins

🟡 widely distributed in in body and concentrated in infected skin, muscle, liver, kidney

🟡 partly secreted in bile and undergoes enterohepatic cycling

🟡 metabolized by acetylation and metabolites are excreted in urine

Reference:

Pharmacology 4th Ed: Tara V Shanbhag, Smita Shenoy