DAPSONE

Poojitha Surgi2 Comments

It is a sulphone, oldest and cheapest ; most widely used for leprosy

MECHANISM OF ACTION

ADVERSE EFFECTS

Dose related hemolytic anemia in G6PD deficiency,

OTHERS: Anorexia, Nausea, Vomiting, Fever, Headache, Allergic dermatitis, Itching, Peripheral neuropathy, Methaemoglobin

Exacerbation of lesions- ‘ sulphone syndrome‘:- fever, dermatitis, pruritis, lymphadenopathy, methaemoglobinaemia, anemia, hepatitis

PHARMACOKINETICS

🟡 Given orally

🟡 almost completely absorbed from gut

🟡 bound to plasma proteins

🟡 widely distributed in in body and concentrated in infected skin, muscle, liver, kidney

🟡 partly secreted in bile and undergoes enterohepatic cycling

🟡 metabolized by acetylation and metabolites are excreted in urine

Reference:

Pharmacology 4th Ed: Tara V Shanbhag, Smita Shenoy

TELL-SHOW-DO TECHNIQUE

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Given by Addlestone in 1959.

TELL: The technique involves verbal explanation of procedures in phrases appropriate to the development level of the patient.

SHOW: Demonstrations for the patient of the visual, auditory, olfactory & tactile aspects of the procedure in a carefully defined, non threatening sett.

DO: And then, without deviating from the explanation & demonstration, completion of the procedure.

This technique is used with communication skills (verbal and nonverbal) & positive reinforcement.

( Positive reinforcement is the presentation of reinforces which increases the frequency of desired behavior)

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