🔹 Etiology:

• Diabetes Mellitus (cell mediated contact hypersensitivity – Type IV)
• Graft-versus-host disease
• Drugs
• Flavouring agents
• Tobacco chewing

🔹 Drugs:

• Antimalarials
• NSAID’s
• Anti-hypertensives
• Hypoglycaemics
• Beta-blockers

🔹 Clinical Features:

➡️ Reticular, erythematous, erosive lesions or ulcerations with whitish streak. Atypical location & absence of bilateral occurrence.

🔹 Histological Features:

• Inflammatory infiltrate – diffuse & extends deep into lamina propria
• ⬆️ no. of civatte bodies
• Perivascular infiltrate seen
• Lichenoid dysplasia

🔹 Prognosis:

• Malignant transformation rate – high
• Months to resolve.

Dr. Mehnaz Memon🖊

References: Shafers Textbook Of Oral Pathology 7Ed