INTERMEDIATES OF THE CITRIC ACID CYCLE

• Oxaloacetate + acetyl-CoA
• Citrate
• Isocitrate
• α-ketoglutarate
• Succinyl CoA
• Succinate
• Fumarate
• Malate

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ENZYMES OF THE CITRIC ACID CYCLE

• Citrate synthase (irreversible)
• Aconitase
• Isocitrate dehydrogenase (irreversible) (NADH produced, CO2 released)
• α-ketoglutarate dehydrogenase ( irreversible) (NADH produced, CO2 released)
• Succinyl CoA thiokinase (GTP produced, CoA released)
• Succinate dehydrogenase (FADH2 produced)
• Fumarase
• Malate dehydrogenase (NADH produced)

FINAL BOOKKEEPING

Acetyl-CoA +3NAD+ + FAD + GDP + Pi + 2H20 –> 2 CO2 + 3NADH + 3H+ + FADH2 + ATP + CoA