Diagnosis Demystified – Case 28

Sections show oral mucosa. In the oral epithelium there is basal-cell crowding and hyperplasia. Atypical mitotic figures are present throughout the thickness of the oral epithelium. The squamous cells show nuclear and cellular pleomorphism, and keratin whorls are present. The rete ridges are drop shaped and individual cell keratinisation is present in some areas.

The diagnosis here is 🔍 Carcinoma in situ! 🦠

In simple terms, it’s like a full-blown drama show happening in the oral epithelium! 🎭 The cells are misbehaving – basal-cell crowding, hyperplasia, and atypical mitotic figures are causing chaos! 🤯🔬

The squamous cells are like divas with nuclear and cellular pleomorphism, and there are even keratin whorls for added glam! 💁‍♀️✨

The rete ridges are shaped like drops, adding some artistic flair, and individual cell keratinisation is stealing the spotlight! 💅🌟

Now, here’s the twist – severe epithelial dysplasia is often considered a prelude to this drama, and together they’re sometimes known as Squamous Intraepithelial Neoplasia Grade 3 (SIN 3)! 📜🌆

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