Histological examination shows sheets of squamous cells supported by fibrous stroma. Keratin pearls are present and there is focal necrosis. The squamous cells are pleomorphic and possess hyperchromatic nuclei. Numerous atypical mitotic figures are present. The invasive front is non-cohesive and there is a moderate chronic inflammatory infiltrate at the invasive front.

Hey, curious minds! 🌟 Let’s dive into some histology secrets! 🕵️‍♀️ Imagine peeping into a microscope and spotting a tissue slide with all the drama – squamous cells forming sheets, keratin pearls, and even focal necrosis! 😱 But that’s not all, the squamous cells look all wild – they’re pleomorphic, with hyperchromatic nuclei and atypical mitotic figures dancing around! 🧪🔬 And guess what? At the front lines, there’s an invasion party going on – non-cohesive and joined by a squad of chronic inflammation! 💥🦠

Hold onto your lab coats, because we’re unveiling the diagnosis – it’s none other than squamous-cell carcinoma! 🦠🔍 This is like a villainous takeover in the world of cells! So, next time you’re in histology class, remember these telltale signs of squamous-cell carcinoma! 📚🩺

RESEARCH – Diagnostic methods and treatment modalities

Squamous-cell carcinoma is a type of oral cancer that can be diagnosed and treated using various options. Diagnostic aids and adjunctive techniques, such as toluidine blue, brush cytology, tissue chemiluminescence, and autofluorescence, can assist in the screening of healthy patients for evidence of cancerous changes or to assess the biologic potential of abnormal mucosal lesions (Lingen et al., 2008). Human papillomavirus (HPV) testing is recommended for oropharyngeal cancer, and treatment options for oropharyngeal squamous-cell carcinoma include radical radiotherapy or transoral surgery and neck dissection (Shah et al., 2016). Additionally, squamous-cell carcinoma of the oral cavity evolves within a field of precancerized oral epithelium, and individuals who have been successfully treated for oral squamous-cell carcinoma are at high risk of developing a recurrence (Feller et al., 2013).