Hey peeps! 🌟 Let’s talk about the coolest thing in dentistry right now – bioactive glass! 🦷💎 This stuff is like magic – it bonds to living tissues and helps regenerate bones and teeth! 😮💪 Made of fancy ingredients like silicon dioxide, calcium oxide, and fluoride, it’s like a superhero dental material! 🦸‍♂️✨ Bioactive glass toothpaste? Yep, it exists! It protects our pearly whites from dental bleaching damage! 🙅‍♀️😁 And get this – it’s used in dental restorations, root canals, and even implants! 😎🚀 Plus, it’s rocking the world of tissue engineering too! 🧪🧬 But hold up, we need more research to unlock its full potential and make sure it’s safe! 💡🔍 So, brace yourselves for the future of dentistry with bioactive glass! 💙🦷

Bioactive glass has gained significant attention in the field of dentistry due to its unique properties and potential applications. Bioactive glass refers to a group of materials that can bond to living tissues and promote the regeneration of hard tissues such as bone and teeth (Skallevold et al., 2019). It is composed of silicon dioxide, sodium dioxide, calcium oxide, and phosphorus pentoxide (Al-Harbi et al., 2021). The addition of fluoride to bioactive glasses has been of great interest in the development of dental biomaterials (Brauer et al., 2009). Fluoride-containing bioactive glasses combine the bone-bonding ability of bioactive glasses with the anticariogenic protection provided by fluoride ions (Pedone et al., 2012). These glasses have been used in various dental applications, including dental restorative materials, mineralizing agents, coating materials for dental implants, pulp capping, root canal treatment, and air abrasion procedures (Skallevold et al., 2019).

The use of bioactive glass in dentistry has been driven by the need for improved dental materials that are biocompatible, regenerative, and compatible with advanced technologies (Montazerian & Zanotto, 2016). Dental glass-ceramics, which are easy to process and have outstanding properties, have gained significant importance in the field (Montazerian & Zanotto, 2016). Bioactive glass-based toothpaste has been developed to protect enamel against the deleterious effects of dental bleaching (Vieira-Junior et al., 2016). Bioactive glass nanoparticles have also been used to modify glass ionomer cement, resulting in increased compressive, tensile, and flexural strengths (Leung et al., 2022). However, further studies are needed to determine the long-term effects of these nanoparticles on the human body before their widespread clinical application in dentistry (Leung et al., 2022).

Bioactive glass has shown promising results in the remineralization of demineralized enamel and dentin, making it a potential material for the management of dental caries (Mei & Chu, 2019). It has been incorporated into toothpastes as a mineralizing and desensitizing agent (Gjorgievska et al., 2013). The release of fluoride ions from acrylic resin modified with bioactive glass has also been studied, highlighting its potential for preventing tooth decay and promoting remineralization (Raszewski et al., 2021).

In addition to its applications in restorative dentistry, bioactive glass has been used in endodontics as a direct pulp capping agent and in periodontology for the regeneration of periodontal bone support (Hanada et al., 2018; Curtis et al., 2010). It has also been incorporated into scaffolds and coatings for tissue engineering purposes, including bone tissue engineering (Covarrubias et al., 2018; Erol-Taygun et al., 2013). The use of bioactive glass in dental implants has been explored, with bioactive glass coatings being applied to zirconia substrates to promote bone bonding and accelerate healing (Zhang & Le, 2020).

Overall, bioactive glass has shown great potential in various dental applications, including restorative materials, mineralizing agents, dental implants, pulp capping, and tissue engineering. Its unique properties, such as biocompatibility, bioactivity, and regenerative capabilities, make it a promising material for the advancement of dentistry. However, further research is needed to fully understand its long-term effects and optimize its properties for specific applications.

REFERENCES

Al-Harbi, N., Mohammed, H., Al-Hadeethi, Y., Bakry, A., Umar, A., Hussein, M., … & Nune, M. (2021). Silica-based Bioactive Glasses and Their Applications In Hard Tissue Regeneration: A Review. Pharmaceuticals, 2(14), 75. https://doi.org/10.3390/ph14020075 Alizadeh-Osgouei, M., Li, Y., Wen, C. (2019). A Comprehensive Review Of Biodegradable Synthetic Polymer-ceramic Composites and Their Manufacture For Biomedical Applications. Bioactive Materials, (4), 22-36. https://doi.org/10.1016/j.bioactmat.2018.11.003 Benetti, F., Queiroz, Í., Oliveira, P., Conti, L., Azuma, M., Oliveira, S., … & Cintra, L. (2019). Cytotoxicity and Biocompatibility Of A New Bioceramic Endodontic Sealer Containing Calcium Hydroxide. Braz. oral res., (33). https://doi.org/10.1590/1807-3107bor-2019.vol33.0042 Brauer, D., Karpukhina, N., Law, R., Hill, R. (2009). Structure Of Fluoride-containing Bioactive Glasses. J. Mater. Chem., 31(19), 5629. https://doi.org/10.1039/b900956f Cannio, M., Bellucci, D., Roether, J., Boccaccini, D., Cannillo, V. (2021). Bioactive Glass Applications: a Literature Review Of Human Clinical Trials. Materials, 18(14), 5440. https://doi.org/10.3390/ma14185440 Covarrubias, C., Cádiz, M., Maureira, M., Celhay, I., Cuadra, F., Marttens, A. (2018). Bionanocomposite Scaffolds Based On Chitosan–gelatin and Nanodimensional Bioactive Glass Particles: In Vitro Properties And In Vivo Bone Regeneration. J Biomater Appl, 9(32), 1155-1163. https://doi.org/10.1177/0885328218759042 Curtis, A., West, N., Su, B. (2010). Synthesis Of Nanobioglass and Formation Of Apatite Rods To Occlude Exposed Dentine Tubules And Eliminate Hypersensitivity. Acta Biomaterialia, 9(6), 3740-3746. https://doi.org/10.1016/j.actbio.2010.02.045 Erol-Taygun, M., Zheng, K., Boccaccini, A. (2013). Nanoscale Bioactive Glasses In Medical Applications. Int J Appl Glass Sci, 2(4), 136-148. https://doi.org/10.1111/ijag.12029 Gjorgievska, E., Nicholson, J., Slipper, I., Stevanovic, M. (2013). Remineralization Of Demineralized Enamel By Toothpastes: a Scanning Electron Microscopy, Energy Dispersive X-ray Analysis, And Three-dimensional Stereo-micrographic Study. Microsc Microanal, 3(19), 587-595. https://doi.org/10.1017/s1431927613000391 Guduric, V., Belton, N., Richter, R., Bernhardt, A., Spangenberg, J., Wu, C., … & Gelinsky, M. (2021). Tailorable Zinc-substituted Mesoporous Bioactive Glass/alginate-methylcellulose Composite Bioinks. Materials, 5(14), 1225. https://doi.org/10.3390/ma14051225 Hanada, K., Morotomi, T., Washio, A., Yada, N., Matsuo, K., Teshima, H., … & Kitamura, C. (2018). in Vitro and in Vivo Effects Of A Novel Bioactive Glass‐based Cement Used As A Direct Pulp Capping Agent. J. Biomed. Mater. Res., 1(107), 161-168. https://doi.org/10.1002/jbm.b.34107 Leung, G., Wong, A., Chu, C., Yu, O. (2022). Update On Dental Luting Materials. Dentistry Journal, 11(10), 208. https://doi.org/10.3390/dj10110208 Mei, M., Chu, C. (2019). Mechanisms Of Bioactive Glass On Caries Management: a Review. Materials, 24(12), 4183. https://doi.org/10.3390/ma12244183 Montazerian, M., Zanotto, E. (2016). Bioactive and Inert Dental Glass-ceramics. J. Biomed. Mater. Res., 2(105), 619-639. https://doi.org/10.1002/jbm.a.35923 Pedone, A., Charpentier, T., Menziani, M. (2012). The Structure Of Fluoride-containing Bioactive Glasses: New Insights From First-principles Calculations and Solid State Nmr Spectroscopy. J. Mater. Chem., 25(22), 12599. https://doi.org/10.1039/c2jm30890h Raszewski, Z., Nowakowska, D., Więckiewicz, W., Nowakowska-Toporowska, A. (2021). Release and Recharge Of Fluoride Ions From Acrylic Resin Modified With Bioactive Glass. Polymers, 7(13), 1054. https://doi.org/10.3390/polym13071054 Skallevold, H., Rokaya, D., Khurshid, Z., Zafar, M. (2019). Bioactive Glass Applications In Dentistry. IJMS, 23(20), 5960. https://doi.org/10.3390/ijms20235960 T, L. (2013). Bioglass: a Novel Biocompatible Innovation. J Adv Pharm Tech Res, 2(4), 78. https://doi.org/10.4103/2231-4040.111523 Vieira-Junior, W., Lima, D., Tabchoury, C., Ambrosano, G., Aguiar, F., Lovadino, J. (2016). Effect Of Toothpaste Application Prior To Dental Bleaching On Whitening Effectiveness and Enamel Properties. Operative Dentistry, 1(41), E29-E38. https://doi.org/10.2341/15-042-l Wang, Z. (2015). Bioceramic Materials In Endodontics. Endod Topics, 1(32), 3-30. https://doi.org/10.1111/etp.12075 Wang, Z., Jiang, T., Sauro, S., Wang, Y., Thompson, I., Watson, T., … & Haapasalo, M. (2011). Dentine Remineralization Induced By Two Bioactive Glasses Developed For Air Abrasion Purposes. Journal of Dentistry, 11(39), 746-756. https://doi.org/10.1016/j.jdent.2011.08.006 Wei, L., Li, Z., Li, J., Zhang, Y., Yao, B., Liu, Y., … & Huang, S. (2020). An Approach For Mechanical Property Optimization Of Cell-laden Alginate–gelatin Composite Bioink With Bioactive Glass Nanoparticles. J Mater Sci: Mater Med, 11(31). https://doi.org/10.1007/s10856-020-06440-3 Wu, C., Gaharwar, A., Schexnailder, P., Schmidt, G. (2010). Development Of Biomedical Polymer-silicate Nanocomposites: a Materials Science Perspective. Materials, 5(3), 2986-3005. https://doi.org/10.3390/ma3052986 Yudaev, P., Chuev, V., Klyukin, B., Rizos, A., Mezhuev, Y., Chistyakov, E. (2022). Polymeric Dental Nanomaterials: Antimicrobial Action. Polymers, 5(14), 864. https://doi.org/10.3390/polym14050864 Zhang, K., Le, Q. (2020). Bioactive Glass Coated Zirconia For Dental Implants: a Review. jcc, 1(2), 10-17. https://doi.org/10.29252/jcc.2.1.2