By Dr Musaddika Shaikh Dentowesome @drmusaddikashaikh

Haemoglobin :- It is protein found in red blood cells that carries oxygen in blood and gives blood red colour

Structure :-

• Heame is porphin called iron protoporphyrine 9th
• Iron is ferrous form which combine with oxygen
• Globin :- It is protein 4 polypeptide chain of alpha and beta which contains Mb amino acid each polypeptide attach are heam group
• Hemoglobin react with oxygen in 0.01 sec
• Molecular weight of hemoglobin 64,458 g/mol
• Oxyheamoglobin :- hemoglobin affinity for oxygen by Ph, temperature, concentration
• Carbaamino-heamoglobin :- carbon dioxide react with heamoglobin to form carbaamino-heamoglobin
• De-oxegenated heamoglobin :- oxygen removed from heamoglobin
• Carboxy-heamoglobin :- carba+monooxide reacts with heamoglobin
• Metheamoglobin :- reduced or oxygenated heamoglobin exposed to drugs is oxidised ferrous to ferric acid metheamoglobin

Normal values of heamoglobin :-

Types :-

Synthesis :-

• Role of protein :- Low protein reduces heamoglobin
• Role of minerals :- It helps in formation of heame
• Role of Cu :- It promotes absorption, mobilization and utilisation of iron
• Role of cobalt :- It enhances absorption in GI tract
• Role of vitamin :- Vit C,Vit B12,folic acid helps in synthesis of nucleic acid

Functions :-

1. Transport of oxygen from lungs to tissues
2. Transport of carbon dioxide from tissues to lungs
3. Act as acid balance buffer
4. It gives red colour to blood
5. Genetic resistance to malaria etc
6. Source of physiological active catabolites

Reference :- Book Human physiology for bds A.K Jain Google website study.com,learnpick.in, redcrossblood.org